Q-PCaP was a follow-up study built upon PCaP. Q-PCaP was designed to collect follow up Health Related Quality of Life (HRQoL) data from the Louisiana cohort of PCaP 3-6 years after their initial baseline interview. Subjects’ current Health Life Behaviors (HLB), social, economic, physical and emotional status, including prostate-related symptoms and other comorbidities, as well as their self-reported experience regarding PCa treatment and health care, were collected via telephone interviews. The presence and degree of any disparity in the HRQoL between AA and CA PCa survivors were evaluated. Results: The study generated a rich archive of follow-up data for a well-characterized population-based cohort of men with PCa to improve understanding of the determinants and disparities in HRQoL. Primary data collection activities yielded approximately 900 PCa survivors. Conclusion: HLBs are potentially modifiable factors affecting the HRQoL of PCa survivorship. Identifying those that contribute the most to HRQoL and instituting interventions to alter “unhealthy” behaviors may make it possible to not only improve overall HRQoL of PCa survivors, but to reduce racial disparities.